Nature's Toolbox (NTx) is a bioinformatics and biomanufacturing company. Its platform enables high-throughput screening and fast prototyping of novel biological materials with defined qualities. Besides cell-free manufacturing, the NTx science allows real-time metabolic profiling of bacteria, fungi, and plants (DruID) to discover, characterize and ultimately produce new chemical entities (NCEs) and biosimilars with increased reproducibility at a reduced footprint and cost. Nature's Toolbox (NTx) aims to provide materials for a diverse product portfolio, to deliver solutions for difficult-to-make biologics, and to generate drug leads for clinical development.