Motif Bio PLC is a United Kingdom-based clinical-stage biopharmaceutical company which specializes in developing antibiotics designed to be effective against serious and life-threatening infections caused by multi-drug resistant bacteria. The Company has a lead antibiotic candidate, Iclaprim, and MTF-001, a preclinical program.-based on iclaprim and other lead compounds, the Company is engaged in the development of a lead series with the objective of identifying a DHFRi that is effective against a broad spectrum of gram positive bacteria, including those resistant to available antibiotics, that can be administered once daily in injectable (I/V) and oral (pill) formulations. The Company's other programs include programs in various-stages of development by building a portfolio of antibiotics by licensing drug candidates from organizations specialized in antibacterial research.