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Karyopharm Therapeutics

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    • Healthcarebiotechdrug developmentoncologypharma

    Karyopharm Therapeutics Inc. is a clinical-stage pharmaceutical company focused on the discovery and development of drugs directed against nuclear transport targets for the treatment of cancer and other diseases. The Company is developing small molecule Selective Inhibitor of Nuclear Export (SINE), compounds that inhibits the nuclear export protein XPO1. Karyopharm is seeking the regulatory approval and commercialization of its lead drug candidate, selinexor (KPT-330), as a single orally administered agent in cancer indications with unmet clinical need, initially for hematologic malignancies. It is also advancing the clinical development of selinexor in multiple solid tumor indications. The Company has initiated three registration-directed trials in hematological cancers with selinexor and anticipates initiating a fourth registration-directed trial.

    Employee Rating

    3.1More
    TypeSubsidiary
    Parent CompanyBiogen
    HQNewton, US
    Founded2008
    Websitekaryopharm.com
    Karyopharm Therapeutics was founded in 2008 and is headquartered in Newton, US
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    Key People/Management at Karyopharm Therapeutics

    Michael Kauffman

    Michael Kauffman

    Chief Executive Officer &Board of Directors
    John McCartney

    John McCartney

    Senior Director, Product Leadership
    Brian Austad

    Brian Austad

    Vice President, Head of Pharmaceutical Sciences
    Dilara McCauley

    Dilara McCauley

    Vice President, Product Leadership
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    Karyopharm Therapeutics Office Locations

    Karyopharm Therapeutics has offices in Newton and München
    Newton, (HQ)
    85 Wells Ave
    München,
    9 Franziska-Bilek-Weg
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    Karyopharm Therapeutics Financials and Metrics

    Summary Metrics

    Founding Date

    		2008

    Total Funding

    		$248.7 m

    Investors

    		Delphi Ventures, New Leaf Venture Partners, Foresite Capital
    Karyopharm Therapeutics is a subsidiary of Biogen

    Karyopharm Therapeutics Revenue

    Karyopharm Therapeutics's revenue was reported to be $250 k in FY, 2015 which is a 9.2% increase from the previous period.
    Annual
    USDFY, 2013FY, 2014FY, 2015FY, 2016FY, 2017

    Revenue

    		387.0k229.0k250.0k

    Revenue growth, %

    		(41%)9%

    General and administrative expense

    		5.9m15.9m21.6m23.9m24.9m

    R&D expense

    		28.5m60.1m97.7m86.9m107.3m
    Quarterly
    USDQ3, 2013Q1, 2014Q2, 2014Q3, 2014Q1, 2015Q2, 2015Q3, 2015Q1, 2016Q2, 2016Q3, 2016Q1, 2017Q2, 2017Q3, 2017Q1, 2018Q2, 2018

    General and administrative expense

    		1.6m2.9m3.3m3.8m5.4m6.2m4.8m5.6m6.0m5.9m6.3m6.6m5.8m7.6m17.1m

    R&D expense

    		7.7m11.0m13.2m16.0m20.8m27.0m25.9m21.8m24.6m19.9m24.1m23.1m25.2m41.3m86.1m

    Operating expense total

    		9.3m13.9m16.5m19.8m26.2m33.2m30.7m27.3m30.5m25.8m30.3m29.8m31.1m48.9m103.2m

    EBIT

    		(9.3m)(13.7m)(16.4m)(19.7m)(26.1m)(33.0m)(30.6m)(27.3m)(30.5m)(25.7m)(30.3m)(29.8m)(31.1m)(38.9m)(73.3m)
    show all
    Annual
    USDFY, 2013FY, 2014FY, 2015FY, 2016FY, 2017

    Cash

    		156.0m150.6m58.4m49.7m69.0m

    Accounts Receivable

    Inventories

    		2.0m2.0m2.0m2.1m

    Current Assets

    		158.0m207.8m177.6m131.6m148.4m
    Quarterly
    USDQ3, 2013Q1, 2014Q2, 2014Q3, 2014Q1, 2015Q2, 2015Q3, 2015Q1, 2016Q2, 2016Q3, 2016Q1, 2017Q2, 2017Q3, 2017Q1, 2018Q2, 2018

    Cash

    		52.9m144.9m132.3m227.1m51.5m24.2m43.5m42.2m37.7m43.9m25.6m55.4m54.5m37.5m119.0m

    Current Assets

    		53.6m147.6m135.3m231.3m249.3m225.3m198.3m138.1m124.2m130.3m112.2m145.7m121.7m133.3m244.6m

    PP&E

    		246.0k322.0k604.0k2.7m3.3m3.2m3.7m3.3m3.2m3.0m2.7m2.5m2.3m2.5m2.6m

    Total Assets

    		55.9m149.3m137.7m235.2m292.0m263.3m237.0m192.1m170.9m183.6m155.4m185.8m163.8m146.4m256.6m
    show all
    Annual
    USDFY, 2013FY, 2014FY, 2015FY, 2016FY, 2017

    Net Income

    		(33.9m)(75.8m)(118.2m)(109.6m)(129.0m)

    Depreciation and Amortization

    		144.0k323.0k634.0k717.0k713.0k

    Inventories

    		(1.4m)(45.0k)(55.0k)(120.0k)

    Accounts Payable

    		664.0k4.5m(2.4m)945.0k909.0k
    Quarterly
    USDQ3, 2013Q1, 2014Q2, 2014Q3, 2014Q1, 2015Q2, 2015Q3, 2015Q1, 2016Q2, 2016Q3, 2016Q1, 2017Q2, 2017Q3, 2017Q1, 2018Q2, 2018

    Net Income

    		(21.8m)(13.7m)(30.1m)(49.8m)(26.1m)(58.8m)(30.4m)(27.1m)(30.2m)(82.6m)(29.9m)(59.3m)(89.9m)(38.5m)(72.1m)

    Depreciation and Amortization

    		106.0k85.0k191.0k292.0k537.0k363.0k539.0k169.0k353.0k

    Accounts Payable

    		673.0k1.7m362.0k7.0m(1.8m)4.6m4.1m4.1m(1.7m)4.2m(1.5m)(2.9m)(773.0k)(1.9m)

    Cash From Operating Activities

    		(20.2m)(22.5m)(38.7m)(48.3m)(64.4m)(46.4m)(68.2m)(34.7m)(72.3m)
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    Karyopharm Therapeutics Operating Metrics

    FY, 2015

    Patents Issued

    		10
    Show all operating metrics
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    Competitors

    Pharmacyclics
    Healthcare - Subsidiary
    Stemline Therapeutics
    Healthcare - Public
    Cascadian Therapeutics
    Healthcare - Subsidiary
    GlycoMimetics
    Healthcare - Public
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    Karyopharm Therapeutics Online and Social Media Presence

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    Karyopharm Therapeutics News and Updates

    October 29, 2018

    Karyopharm Therapeutics Announces Closing of Additional $22.5 Million of 3.00% Convertible Senior Notes Due 2025 Pursuant to Exercise in Full of Initial Purchasers’ Option

    NEWTON, Mass., Oct. 29, 2018 (GLOBE NEWSWIRE) -- Karyopharm Therapeutics Inc. (Nasdaq:KPTI), a clinical-stage pharmaceutical company, today announced that it has issued an additional $22.5 million aggregate principal amount of its 3.00% convertible senior notes due 2025 (the “notes”) pursuant to t…
    October 26, 2018

    Karyopharm Therapeutics Announces Management Change

    August 03, 2018

    Karyopharm Therapeutics Reports Inducement Grants Under NASDAQ Listing Rule 5635(c)(4)

    NEWTON, Mass., Aug. 03, 2018 (GLOBE NEWSWIRE) -- Karyopharm Therapeutics Inc. (Nasdaq:KPTI), a clinical-stage pharmaceutical company, today announced that the Compensation Committee of Karyopharm’s Board of Directors granted stock options to purchase an aggregate of 196,500 shares of Karyopharm’s …
    May 07, 2018

    Reader Inquiry: Is Karyopharm Therapeutics A Buy After The Secondary Offering?

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    Karyopharm Therapeutics Blogs

    October 11, 2018

    Karyopharm Therapeutics Announces Pricing of $150 Million of Convertible Senior Notes

    Karyopharm Therapeutics Announces Pricing of $150 Million of Convertible Senior Notes Content Import Thu, 10/11/2018 - 07:03 Karyopharm Therapeutics Announces Pricing of $150 Million of Convertible Senior Notes Oct 11, 2018 This release is a backfill from a Ne…
    October 09, 2018

    Karyopharm Therapeutics Announces Proposed Private Offering of $150 Million of Convertible Senior Notes

    Karyopharm Therapeutics Announces Proposed Private Offering of $150 Million of Convertible Senior Notes Content Import Tue, 10/09/2018 - 16:03 Karyopharm Therapeutics Announces Proposed Private Offering of $150 Million of Convertible Senior Notes Oct 9, 2018 T…
    September 20, 2018

    Selinexor Clinical Data to be Presented at the 21st Annual Meeting of the Chinese Society of Clinical Oncology

    -- Two Oral Presentations Highlighting Previously Reported Phase 2b STORM Data in Patients with Penta-Refractory Multiple Myeloma and Phase 2b SADAL Data in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma -- -- One Poster Presentation Featuring Previously Reported Phase 1b/2
    September 18, 2018

    Ian Karp

    Ian Karp Brian.Hoenig@n… Tue, 09/18/2018 - 12:54 Ian Karp Vice President, Investor and Public Relations Ian is responsible for leading Karyopharm’s corporate communications activities, including corporate visibility, financial communicat…
    August 06, 2018

    Karyopharm Completes Rolling Submission of New Drug Application to U.S. Food and Drug Administration for Selinexor as a Treatment for Patients with Penta-Refractory Multiple Myeloma

    --     Company to Host Conference Call to Discuss Second Quarter 2018 Financial Results and Recent Business Developments on Tuesday, August 7, 2018 at 8:30 a.m. ET --  NEWTON, Mass. , Aug. 06, 2018 (GLOBE NEWSWIRE) -- Karyopharm Therapeutics Inc. (Nasdaq:KPTI), a clinical-stage pharmaceutical
    July 25, 2018

    Karyopharm Appoints Ian Karp as Vice President, Investor and Public Relations

    --  Formerly of Shire, MedImmune, Centocor and Pharmacia; Brings Over 20 Years of Healthcare Industry Leadership Experience --  NEWTON, Mass. , July 25, 2018 (GLOBE NEWSWIRE) -- Karyopharm Therapeutics Inc. (Nasdaq:KPTI), a clinical-stage pharmaceutical company, today announced the appointment of
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    Karyopharm Therapeutics Company Life and Culture

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     Karyopharm Therapeutics Frequently Asked Questions

    • When was Karyopharm Therapeutics founded?

      Karyopharm Therapeutics was founded in 2008.

    • Who are Karyopharm Therapeutics key executives?

      Karyopharm Therapeutics's key executives are Michael Kauffman, John McCartney and Brian Austad.

    • Who are Karyopharm Therapeutics competitors?

      Competitors of Karyopharm Therapeutics include Pharmacyclics, Stemline Therapeutics and Cascadian Therapeutics.

    • Where is Karyopharm Therapeutics headquarters?

      Karyopharm Therapeutics headquarters is located at 85 Wells Ave, Newton.

    • Where are Karyopharm Therapeutics offices?

      Karyopharm Therapeutics has offices in Newton and München.

    • How many offices does Karyopharm Therapeutics have?

      Karyopharm Therapeutics has 2 offices.