Karyopharm Therapeutics Inc. is a clinical-stage pharmaceutical company focused on the discovery and development of drugs directed against nuclear transport targets for the treatment of cancer and other diseases. The Company is developing small molecule Selective Inhibitor of Nuclear Export (SINE), compounds that inhibits the nuclear export protein XPO1. Karyopharm is seeking the regulatory approval and commercialization of its lead drug candidate, selinexor (KPT-330), as a single orally administered agent in cancer indications with unmet clinical need, initially for hematologic malignancies. It is also advancing the clinical development of selinexor in multiple solid tumor indications. The Company has initiated three registration-directed trials in hematological cancers with selinexor and anticipates initiating a fourth registration-directed trial.

Employee Rating

3.1More
TypeSubsidiary
Parent CompanyBiogen
HQNewton, US
Founded2008
Websitekaryopharm.com
Karyopharm Therapeutics was founded in 2008 and is headquartered in Newton, US
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Key People/Management at Karyopharm Therapeutics

Michael Kauffman

Michael Kauffman

Chief Executive Officer &Board of Directors
John McCartney

John McCartney

Senior Director, Product Leadership
Brian Austad

Brian Austad

Vice President, Head of Pharmaceutical Sciences
Dilara McCauley

Dilara McCauley

Vice President, Product Leadership
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Karyopharm Therapeutics Office Locations

Karyopharm Therapeutics has offices in Newton and München
Newton, US (HQ)
85 Wells Ave
München, DE
9 Franziska-Bilek-Weg
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Karyopharm Therapeutics Financials and Metrics

Summary Metrics

Founding Date

2008

Total Funding

$248.7 m

Investors

Karyopharm Therapeutics is a subsidiary of Biogen

Karyopharm Therapeutics Revenue

Karyopharm Therapeutics's revenue was reported to be $250 k in FY, 2015 which is a 9.2% increase from the previous period.
Annual
USDFY, 2013FY, 2014FY, 2015FY, 2016FY, 2017FY, 2018

Revenue

387.0k229.0k250.0k

Revenue growth, %

(41%)9%

General and administrative expense

5.9m15.9m21.6m23.9m24.9m48.8m

R&D expense

28.5m60.1m97.7m86.9m107.3m161.4m
Quarterly
USDQ3, 2013Q1, 2014Q2, 2014Q3, 2014Q1, 2015Q2, 2015Q3, 2015Q1, 2016Q2, 2016Q3, 2016Q1, 2017Q2, 2017Q3, 2017Q1, 2018Q2, 2018

General and administrative expense

1.6m2.9m3.3m3.8m5.4m6.2m4.8m5.6m6.0m5.9m6.3m6.6m5.8m7.6m17.1m

R&D expense

7.7m11.0m13.2m16.0m20.8m27.0m25.9m21.8m24.6m19.9m24.1m23.1m25.2m41.3m86.1m

Operating expense total

9.3m13.9m16.5m19.8m26.2m33.2m30.7m27.3m30.5m25.8m30.3m29.8m31.1m48.9m103.2m

EBIT

(9.3m)(13.7m)(16.4m)(19.7m)(26.1m)(33.0m)(30.6m)(27.3m)(30.5m)(25.7m)(30.3m)(29.8m)(31.1m)(38.9m)(73.3m)
Annual
USDFY, 2013FY, 2014FY, 2015FY, 2016FY, 2017FY, 2018

Cash

156.0m150.6m58.4m49.7m69.0m118.0m

Accounts Receivable

Inventories

2.0m2.0m2.0m2.1m

Current Assets

158.0m207.8m177.6m131.6m148.4m334.6m
Quarterly
USDQ3, 2013Q1, 2014Q2, 2014Q3, 2014Q1, 2015Q2, 2015Q3, 2015Q1, 2016Q2, 2016Q3, 2016Q1, 2017Q2, 2017Q3, 2017Q1, 2018Q2, 2018

Cash

52.9m144.9m132.3m227.1m51.5m24.2m43.5m42.2m37.7m43.9m25.6m55.4m54.5m37.5m119.0m

Current Assets

53.6m147.6m135.3m231.3m249.3m225.3m198.3m138.1m124.2m130.3m112.2m145.7m121.7m133.3m244.6m

PP&E

246.0k322.0k604.0k2.7m3.3m3.2m3.7m3.3m3.2m3.0m2.7m2.5m2.3m2.5m2.6m

Total Assets

55.9m149.3m137.7m235.2m292.0m263.3m237.0m192.1m170.9m183.6m155.4m185.8m163.8m146.4m256.6m
Annual
USDFY, 2013FY, 2014FY, 2015FY, 2016FY, 2017FY, 2018

Net Income

(33.9m)(75.8m)(118.2m)(109.6m)(129.0m)(178.4m)

Depreciation and Amortization

144.0k323.0k634.0k717.0k713.0k735.0k

Inventories

(1.4m)(45.0k)(55.0k)(120.0k)

Accounts Payable

664.0k4.5m(2.4m)945.0k909.0k(1.4m)
Quarterly
USDQ3, 2013Q1, 2014Q2, 2014Q3, 2014Q1, 2015Q2, 2015Q3, 2015Q1, 2016Q2, 2016Q3, 2016Q1, 2017Q2, 2017Q3, 2017Q1, 2018Q2, 2018

Net Income

(21.8m)(13.7m)(30.1m)(49.8m)(26.1m)(58.8m)(30.4m)(27.1m)(30.2m)(82.6m)(29.9m)(59.3m)(89.9m)(38.5m)(72.1m)

Depreciation and Amortization

106.0k85.0k191.0k292.0k537.0k363.0k539.0k169.0k353.0k

Accounts Payable

673.0k1.7m362.0k7.0m(1.8m)4.6m4.1m4.1m(1.7m)4.2m(1.5m)(2.9m)(773.0k)(1.9m)

Cash From Operating Activities

(20.2m)(22.5m)(38.7m)(48.3m)(64.4m)(46.4m)(68.2m)(34.7m)(72.3m)
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Karyopharm Therapeutics Operating Metrics

FY, 2015

Patents Issued

10
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Karyopharm Therapeutics Online and Social Media Presence

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Karyopharm Therapeutics News and Updates

Karyopharm Therapeutics Announces Closing of Additional $22.5 Million of 3.00% Convertible Senior Notes Due 2025 Pursuant to Exercise in Full of Initial Purchasers’ Option

NEWTON, Mass., Oct. 29, 2018 (GLOBE NEWSWIRE) -- Karyopharm Therapeutics Inc. (Nasdaq:KPTI), a clinical-stage pharmaceutical company, today announced that it has issued an additional $22.5 million aggregate principal amount of its 3.00% convertible senior notes due 2025 (the “notes”) pursuant to t…

Karyopharm Therapeutics Reports Inducement Grants Under NASDAQ Listing Rule 5635(c)(4)

NEWTON, Mass., Aug. 03, 2018 (GLOBE NEWSWIRE) -- Karyopharm Therapeutics Inc. (Nasdaq:KPTI), a clinical-stage pharmaceutical company, today announced that the Compensation Committee of Karyopharm’s Board of Directors granted stock options to purchase an aggregate of 196,500 shares of Karyopharm’s …
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Karyopharm Therapeutics Blogs

Karyopharm to Report Fourth Quarter and Full Year 2018 Financial Results on February 28, 2019

Karyopharm to Report Fourth Quarter and Full Year 2018 Financial Results on February 28, 2019 Content Import Thu, 02/21/2019 - 07:08 Karyopharm to Report Fourth Quarter and Full Year 2018 Financial Results on February 28, 2019 Feb 21, 2019 This release is a ba…

Karyopharm Announces FDA Advisory Committee Meeting to Review Selinexor for the Treatment of Patients with Triple Class Refractory Multiple Myeloma Who Have Received At Least Three Prior Therapies

NEWTON, Mass. , Feb. 07, 2019 (GLOBE NEWSWIRE) -- Karyopharm Therapeutics Inc. (Nasdaq:KPTI), a clinical-stage pharmaceutical company, today announced that the Oncologic Drugs Advisory Committee (ODAC) of the U.S. Food and Drug Administration (FDA) is scheduled to review data supporting the

Tanya Lewis

Tanya Lewis alfredo.macaba… Thu, 01/17/2019 - 09:23 Tanya Lewis Senior Vice President, Regulatory Affairs Tanya joined Karyopharm in October 2018 and is responsible for the company’s regulatory affairs strategy and operations. Tanya is a…

Karyopharm to Present at the 37th Annual J.P. Morgan Healthcare Conference

NEWTON, Mass. , Jan. 02, 2019 (GLOBE NEWSWIRE) -- Karyopharm Therapeutics Inc. (Nasdaq:KPTI), a clinical-stage pharmaceutical company, today announced that Michael Kauffman , MD, PhD, Chief Executive Officer, will present at the 37 th Annual J.P. Morgan Healthcare Conference on Monday, January 7,

Karyopharm Reports Updated Selinexor Data from the Phase 2b STORM and Phase 1b/2 STOMP Studies in Relapsed/Refractory Multiple Myeloma at the American Society of Hematology 2018 Annual Meeting

-- Oral Selinexor Achieves 26.2% Overall Response Rate in STORM Study, 4.4 Month Median Duration of Response, 8.6 Month Median Overall Survival and 15.6 Month Median Survival in Patients with MR or Better -- -- Once Weekly Oral Selinexor in Combination with Darzalex ® and Low Dose Dexamethasone

Karyopharm Therapeutics Announces Pricing of $150 Million of Convertible Senior Notes

Karyopharm Therapeutics Announces Pricing of $150 Million of Convertible Senior Notes Content Import Thu, 10/11/2018 - 07:03 Karyopharm Therapeutics Announces Pricing of $150 Million of Convertible Senior Notes Oct 11, 2018 This release is a backfill from a Ne…
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Karyopharm Therapeutics Frequently Asked Questions

  • When was Karyopharm Therapeutics founded?

    Karyopharm Therapeutics was founded in 2008.

  • Who are Karyopharm Therapeutics key executives?

    Karyopharm Therapeutics's key executives are Michael Kauffman, John McCartney and Brian Austad.

  • Who are Karyopharm Therapeutics competitors?

    Competitors of Karyopharm Therapeutics include Heidelberg Pharma, MEI Pharma and Oncopeptides.

  • Where is Karyopharm Therapeutics headquarters?

    Karyopharm Therapeutics headquarters is located at 85 Wells Ave, Newton.

  • Where are Karyopharm Therapeutics offices?

    Karyopharm Therapeutics has offices in Newton and München.

  • How many offices does Karyopharm Therapeutics have?

    Karyopharm Therapeutics has 2 offices.