ApoGen Biotechnologies is developing novel oncology therapeutics targeting the key drivers of mutation and cancer genomic evolution to overcome drug resistance. Our lead target is APOBEC3B (A3B), a DNA cytosine deaminase and an important endogenous source of DNA mutation in cancer. A3B was recently identified as a dominant source of the characteristic C-to-T mutational pattern and higher overall mutational load seen in numerous cancers. Elevated levels of A3B were shown to be a key driver in the formation of cancers including breast, head and neck, lung, bladder, cervical, ovarian, myeloma, and some blood cancers. ApoGen’s drug discovery and development efforts are directed toward highly selective and potent small molecule inhibitors of A3B. These inhibitors aim to slow or stop cancer genome mutation and the development of drug resistance, potentially increasing the effectiveness of current and future therapies.
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